Proxerex: scientific evidence
All of this product's scientific content in one place: a summary of the evidence level, the published references, and the verified studies with their limits. For the product itself and how to use it, go back to the product page.
Back to the product page ↗Evidence summary
The scientific evidence for Proxerex's formula is at the individual-ingredient level, and is relatively modest. Niacin is studied in a real placebo-controlled clinical trial, but specifically in moderate-to-severe erectile dysfunction. Maca extract is studied for a modest effect on sexual desire, independent of testosterone level. There is no evidence that the product raises testosterone levels, and no such claim is made.
Clinical References
- Effect of niacin on erectile function in men suffering erectile dysfunction and dyslipidemiaNg CF et al., J Sex Med · 2011View source ↗
Verified studies & what they mean
Approved doctor message — verbatim from the approved reference:
“Wellness food supplement, not an ED treatment; 3 small open-label product studies without placebo; L-arginine 2.5 g has moderate-grade context (EAU 2025 +2.74 IIEF).”
Approved usage: 1 sachet/day per leaflet; wellness only.
Mandatory safety notices
- Not a substitute for medical ED advice.
- Effect smaller than approved medicines.
Confirmed claims — approved wording
Wellness support only Allowed
“Food supplement within a healthy lifestyle; not an ED treatment.”
L-arginine 2.5 g context Restricted
“Ingredient-level moderate: EAU 2025 +2.74 IIEF; Rhim meta OR 3.37 with heterogeneity.”
State as ingredient context, not product proof.
Preliminary — always stated with limits
Ezerex open studies Preliminary
“3 open studies without placebo described within-group IIEF changes; no comparative efficacy.”
What must not be claimed — forbidden wording
ED treatment Unsupported / Forbidden
Forbidden: “يعالج ضعف الانتصاب / بديل الفياجرا”
Do not use — not a treatment.
SUCRA 97% inflated ranking Unsupported / Forbidden
Forbidden: claim SUCRA 97% (actual 52%) or inflate effect size.
Verified studies — with original reference link (DOI / PMID / PMCID)
Five non-negotiable rules applied: no cross-product attribution, no dose borrowing, surrogate ≠ outcome, no generalisation without data, no claim without link.
- Layer A · مفتوحة، قبل↔بعد48 رجل ضعف خفيف-متوسطVery limitedL-citrulline 800 mg→L-arginine · 4 أسابيع
Effect of a compound containing L-citrulline + trans-resveratrol on erectile function (Ezerex prototype)
Gentile et al., Phytomedicine · Phytomedicine · 2009
IIEF-EF +5 in mild ED; no placebo
Limitations: No placebo; small; formulation overlap partial
- Layer A · مفتوحة قبل↔بعد40 رجلVery limitedكيس/يوم · 3 أشهر
Observational study on Ezerex (L-arginine 2.5 g + OPC) in mild-moderate ED
Cormio et al., Arch Ital Urol Androl · Arch Ital Urol Androl · ~2011
Within-group IIEF improvement (p<0.05)
Limitations: No placebo; subjective endpoint
- Layer A · مفتوحة50 رجلVery limitedكيس/يوم
Trans-resveratrol + L-citrulline in mild ED: pilot open study
Gianfrilli et al. · J Endocrinol Invest · 2012
Mild EF improvement (not prespecified primary)
Limitations: No placebo; formulation drift
- Layer C · ميتا 10 RCT540 مريض ضعف انتصابModerateمتنوع 1.5–5 g
L-arginine for erectile dysfunction: systematic review & meta-analysis of RCTs (10 trials, 540 pts) OR 3.37 for ED improvement
Rhim et al., J Sex Med · J Sex Med · 2019
OR 3.37 favouring L-arginine; high heterogeneity
Limitations: Dose/duration heterogeneity; moderate certainty; not product-specific
- Layer C · ميتا شبكي 15 RCTإطار شبكيModerateمتنوع
Network meta-analysis of nutraceuticals for ED — SUCRA ranking L-arginine 52%
Barbonetti et al., J Sex Med · J Sex Med · 2024
SUCRA 52% (not 97%) — common misread
Limitations: Ranking ≠ clinical recommendation
- Layer C · RCT—Limited2.5 g/يوم
L-arginine 2.5 g vs placebo in mild-moderate ED (Gallo et al.)
Gallo et al., Sex Med · Sex Med · 2020
IIEF 15 → 18.1 (EAU 2025 delta +2.74)
Limitations: Modest effect; not a substitute for guideline therapy
Studies link directly to their original PubMed / DOI / PMC records only.
Every claim and study above matches the approved internal reference verbatim; the five non-negotiable rules (§2) are enforced.
Related research reviews
Information to help you understand a product, not a treatment recommendation. Consult your doctor or pharmacist before use.